Article

Shedding Light on the Dark Genome: Insights into the Genetic, CRISPR-based, and Pharmacological Dependencies of Human Cancers and Disease Aggressiveness

2023-08-17

Abstract excerpt

Investigating the human genome is vital for identifying risk factors and devising effective therapies to combat genetic disorders and cancer. Despite the extensive knowledge of the “light genome”, the poorly understood “dark genome” remains understudied. In this study, we integrated data from 20,412 protein-coding genes in Pharos and 8,395 patient-derived tumours from The Cancer Genome Atlas (TCGA) to examine the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7a247123-b4e4-5271-a716-fdc64bff4b25
DOI: 10.1101/2023.08.15.552589

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Shedding Light on the Dark Genome: Insights into the Genetic, CRISPR-based, and Pharmacological Dependencies of Human Cancers and Disease AggressivenessDOI 10.1101/2023.08.15.552589Read

Shedding light on the dark genome: Insights into the genetic, CRISPR-based, and pharmacological dependencies of human cancers and disease aggressiveness.Semantic proximity Read

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.Semantic proximity Read

CRISPR Functional Genomics in Precision Oncology: Integrating Single-Cell Multi-Omics for Cancer Vulnerability DiscoverySemantic proximity Read

A blueprint for mutation-defined hallmark vulnerabilities across human cancersSemantic proximity Read

Mutational signatures are markers of drug sensitivity of cancer cells.Semantic proximity Read

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic ArchitectureSemantic proximity Read

A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization.Semantic proximity Read

Methods and resources to access mutation-dependent effects on cancer drug treatment.Semantic proximity Read

The mutational footprints of cancer therapiesSemantic proximity Read

Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies.Semantic proximity Read

Integrated Molecular Characterisation of the MAPK Pathways in Human CancersSemantic proximity Read

Genomic sites hypersensitive to ultraviolet radiation.Semantic proximity Read