Article

Targeting the FBXL12-FANCD2 Pathway Disrupts Replication Stress Tolerance in MYCN-Driven Neuroblastoma

2026-08-31

Abstract excerpt

MYCN amplification drives replication stress in high-risk neuroblastoma, yet how MYCN-amplified tumour cells tolerate this stress to sustain proliferation remains poorly understood. Here we show that FBXL12, an SCF ubiquitin ligase substrate receptor that targets the Fanconi anaemia protein FANCD2 for degradation at replication forks, as well as the broader Fanconi anaemia and replication stress transcriptional pr...

Identifiers and source

Literature Corpus work: 7a23afc7-f154-57bc-b794-9ebe28cdeab8
DOI: 10.64898/2026.08.29.745966

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Targeting the FBXL12-FANCD2 Pathway Disrupts Replication Stress Tolerance in MYCN-Driven NeuroblastomaDOI 10.64898/2026.08.29.745966Read

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