Article

Overexpression of Proteins Involved in Mitotic Progression Underlies High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer

2025-10-08

Abstract excerpt

Triple-negative breast cancer (TNBC), particularly the androgen receptor–low (AR-low) subtype, is one of the most aggressive and hard-to-treat forms of breast cancer, characterized by high index of proliferation, chromosomal instability (CIN), and high prevalence of TP53 mutations. These features fuel intra-tumoral heterogeneity, therapy resistance, and poor clinical outcomes. An integrated framework that encompas...

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Literature Corpus work: 03564b70-1710-56ce-a803-e8af7543735d
DOI: 10.20944/preprints202510.0602.v1

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