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Article

Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells

10 Dec 2021

Abstract excerpt

Despite intensive high-dose multimodal therapy, high-risk neuroblastoma (NB) confers a less than 50% survival rate. This study investigates the role of replication stress in sensitivity to inhibition of Ataxia telangiectasia and Rad3-related (ATR) in pre-clinical models of high-risk NB. Amplification of the oncogene MYCN always imparts high-risk disease and occurs in 25% of all NB. Here, we show that MYCN-induced...

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PMID: 34944835
DOI: 10.3390/cancers13246215

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