Article

DNA repair and replicative stress addiction in neuroblastoma

2024-07-08

Abstract excerpt

Neuroblastoma (NB) is a pediatric tumor of the sympathetic nervous system. Survival remains poor for the almost 40 % of patients with high-risk NB. Targeted therapy options for high-risk NB are limited and single compound strategies often fail due to escape mechanisms, driven either by tumor heterogeneity or adaptive (epigenetic) responses or mutations. Novel NB therapeutic approaches rely increasingly on biomarke...

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Literature Corpus work: 9c2b661a-cb17-52cf-99a2-6f8e319cfe2f
DOI: 10.1016/j.ejcped.2024.100177

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