Article
The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma.
Mutation research - 1 Jan 2000
Romick-Rosendale Lindsey E, Lui Vivian W Y, Grandis Jennifer R, Wells Susanne I
Abstract excerpt
Fanconi anemia (FA) is a rare inherited recessive disease caused by mutations in one of fifteen genes known to encode FA pathway components. In response to DNA damage, nuclear FA proteins associate into high molecular weight complexes through a cascade of post-translational modifications and physical interactions, followed by the repair of damaged DNA. Hematopoietic cells are particularly sensitive to the loss of...
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