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Article

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

30 Aug 2018

Abstract excerpt

MRE11 is a component of the MRE11/RAD50/NBS1 (MRN) complex, whose activity is essential to control faithful DNA replication and to prevent accumulation of deleterious DNA double-strand breaks. In humans, hypomorphic mutations in these genes lead to DNA damage response (DDR)-defective and cancer-prone syndromes. Moreover, MRN complex dysfunction dramatically affects the nervous system, where MRE11 is required to...

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PMID: 30166519
DOI: 10.1038/s41419-018-0924-z

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