Article

Implications of<i>MGMT</i>promoter methylation and its downstream<i>hMSH2</i>mRNA in primary malignant glioma

2019-10-18

Abstract excerpt

<h4>Background</h4> Hypermethylation of 06-methylguanine DNA methyltransferase ( MGMT) promoter seen in high grade gliomas (HGG) leads to the accumulation of O6-meG DNA damage which mispairs with thymine, requiring recognition by mismatch repair protein dimer MutSα, whose primary component is coded by Human MutS homolog protein 2 ( hMSH2) . O6-meG repair necessitates the interaction/combined action of MGMT andhMSH...

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Literature Corpus work: 7a218e4e-7db2-5ec5-9558-866bdc086ad6
DOI: 10.1101/19008763

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