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Article

Predictive impact of <i>MGMT</i> promoter methylation in glioblastoma of the elderly

3 Dec 2011

Abstract excerpt

O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation identifies a subpopulation of glioblastoma patients with more favorable prognosis and predicts a benefit from alkylating agent chemotherapy (CT). Little is known about its prevalence and clinical significance in older glioblastoma patients. We studied 233 glioblastoma patients aged 70 years or more (144 males, 89 females, median age: 74 years,...

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Share to Epigenetics and DNA Methylation
Share to Glioma Diagnosis and Treatment
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PMID: 22139906
DOI: 10.1002/ijc.27385

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