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<i>MGMT-</i>Methylated Alleles Are Distributed Heterogeneously Within Glioma Samples Irrespective of<i>IDH</i>Status and Chromosome 10q Deletion

26 Jun 2016

Abstract excerpt

Several molecular markers drive diagnostic classification, prognostic stratification, and/or prediction of response to therapy in patients with gliomas. Among them, IDH gene mutations are valuable markers for defining subtypes and are strongly associated with epigenetic silencing of the methylguanine DNA methyltransferase (MGMT) gene. However, little is known about the percentage of MGMT-methylated alleles in...

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PMID: 27346749
DOI: 10.1093/jnen/nlw052

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