Promoter methylation and expression of <i>MGMT</i> and the DNA mismatch repair genes <i>MLH1, MSH2, MSH6</i> and <i>PMS2</i> in paired primary and recurrent glioblastomas

Abstract excerpt

Epigenetic silencing of the O(6) -methylguanine-DNA methyltransferase (MGMT) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). We investigated whether glioblastoma recurrence is associated with changes in the promoter methylation status and the expression of MGMT and the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 in pairs of primary and...

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