Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>O</i> 6 <i>-Methylguanine-DNA Methyltransferase</i> Gene: Epigenetic Silencing and Prognostic Value in Head and Neck Squamous Cell Carcinoma

1 Jun 2004

Abstract excerpt

BACKGROUND: Alkylating N-nitroso compounds can interact directly with DNA, forming O(6)-alkylguanine, a DNA adduct proved to be mutagenic and carcinogenic if not sufficiently repaired. A specific DNA repair enzyme, O(6)-methylguanine-DNA methyltransferase (MGMT), can remove the alkyl group from the O(6)-position of the guanine, thereby preventing its mutagenic and carcinogenic effects. Inactivation of the MGMT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Epigenetics and DNA Methylation
Share to Glioma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15184253
DOI: 10.1158/1055-9965.967.13.6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>O</i> 6 <i>-Methylguanine-DNA Methyltransferase</i> Gene: Epigenetic Silencing and Prognostic Value in Head and Neck Squamous Cell CarcinomaPMID 15184253Read ↗

Promoter hypermethylation of mismatch repair genes, <i>hMLH1</i> and <i>hMSH2</i> in oral squamous cell carcinomaSemantic proximity Read ↗

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.Semantic proximity Read ↗

<i>O</i><sup>6</sup>‐methylguanine‐DNA methyltranspherase gene expression in gliomas by means of real‐time quantitative RT‐PCR and clinical response to nitrosoureasSemantic proximity Read ↗

Promoter methylation and loss of <i>p16</i><sup><i>INK4a</i></sup> gene expression in head and neck cancerSemantic proximity Read ↗

Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylationSemantic proximity Read ↗

Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancerSemantic proximity Read ↗

Inactivation of the DNA-Repair Gene <i>MGMT</i> and the Clinical Response of Gliomas to Alkylating AgentsSemantic proximity Read ↗

MGMT gene silencing by promoter hypermethylation in gastric cancer in a high incidence areaSemantic proximity Read ↗

The role of MGMT polymorphisms rs12917 and rs11016879 in head and neck cancer risk and prognosis.Semantic proximity Read ↗

Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.Semantic proximity Read ↗

Promoter methylation and expression of <i>MGMT</i> and the DNA mismatch repair genes <i>MLH1, MSH2, MSH6</i> and <i>PMS2</i> in paired primary and recurrent glioblastomasSemantic proximity Read ↗

Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.