Article
IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme.
Gene - 1 Jan 2015
Kalkan Rasime, Atli Emine İkbal, Özdemir Muhsin, Çiftçi Evrim, Aydin Hasan Emre, Artan Sevilhan, Arslantaş Ali
Abstract excerpt
PURPOSE: To establish the frequency of IDH1 mutations and MGMT methylation in primary glioblastomas. EXPERIMENTAL DESIGN: We screened primary glioblastoma multiforme (GBM) in a population-based study for IDH1 mutations and MGMT methylation and correlated them with clinical data. RESULTS: IDH1 mutations were detected in 5 of 40 primary glioblastomas (12,5%). Primary GBM patients carrying IDH1 mutations were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.