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Extent and Patterns of <i>MGMT</i> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres

19 Nov 2010

Abstract excerpt

PURPOSE: Quantitative methylation-specific tests suggest that not all cells in a glioblastoma with detectable promoter methylation of the O6-methylguanine DNA methyltransferase (MGMT) gene carry a methylated MGMT allele. This observation may indicate cell subpopulations with distinct MGMT status, raising the question of the clinically relevant cutoff of MGMT methylation therapy. Epigenetic silencing of the MGMT...

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PMID: 21097691
DOI: 10.1158/1078-0432.ccr-10-1931

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