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Article

Integrated analysis of mismatch repair system in malignant astrocytomas.

PloS one - 1 Jan 2013

Rodríguez-Hernández Irene, Garcia Juan Luis, Santos-Briz Angel, Hernández-Laín Aurelio, González-Valero Jose María, Gómez-Moreta Juan Antonio, Toldos-González Oscar, Cruz Juan Jesús, Martin-Vallejo Javier, González-Sarmiento Rogelio

Abstract excerpt

Malignant astrocytomas are the most aggressive primary brain tumors with a poor prognosis despite optimal treatment. Dysfunction of mismatch repair (MMR) system accelerates the accumulation of mutations throughout the genome causing uncontrolled cell growth. The aim of this study was to characterize the MMR system defects that could be involved in malignant astrocytoma pathogenesis. We analyzed protein expression...

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Share to Astrocytoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24073290
DOI: 10.1371/journal.pone.0076401
PMCID: PMC3779191

Genes

MLH1
MSH6
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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