Article

Pleiotropic Influence of DNA Methylation QTLs on physiological and aging traits

2023-04-13

Abstract excerpt

DNA methylation is influenced by genetic and non-genetic factors. Here, we chart quantitative trait loci (QTLs) that modulate levels of methylation at highly conserved CpGs using liver methylome data from mouse strains belonging to the BXD Family. A regulatory hotspot on chromosome 5 had the highest density of trans-acting methylation QTLs (trans-meQTLs) associated with multiple distant CpGs. We refer to this locu...

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Literature Corpus work: 7a1cfe13-d648-5e7f-8d77-3571d362ade8
DOI: 10.1101/2023.04.12.536608

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