Article
Genome-level analysis of genetic regulation of liver gene expression networks.
Hepatology (Baltimore, Md.) - 1 Aug 2007
Gatti Daniel, Maki Akira, Chesler Elissa J, Kirova Roumyana, Kosyk Oksana, Lu Lu, Manly Kenneth F, Williams Robert W, Perkins Andy, Langston Michael A, Threadgill David W, Rusyn Ivan
Abstract excerpt
UNLABELLED: The liver is the primary site for the metabolism of nutrients, drugs, and chemical agents. Although metabolic pathways are complex and tightly regulated, genetic variation among individuals, reflected in variations in gene expression levels, introduces complexity into research on liver disease. This study dissected genetic networks that control liver gene expression through the combination of...
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