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Article

Genetic effects on DNA methylation and its potential relevance for obesity in Mexican Americans.

PloS one - 1 Jan 2013

Carless Melanie A, Kulkarni Hemant, Kos Mark Z, Charlesworth Jac, Peralta Juan M, Göring Harald H H, Curran Joanne E, Almasy Laura, Dyer Thomas D, Comuzzie Anthony G, Mahaney Michael C, Blangero John

Abstract excerpt

Several studies have identified effects of genetic variation on DNA methylation patterns and associated heritability, with research primarily focused on Caucasian individuals. In this paper, we examine the evidence for genetic effects on DNA methylation in a Mexican American cohort, a population burdened by a high prevalence of obesity. Using an Illumina-based platform and following stringent quality control...

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17-Hydroxysteroid Dehydrogenases
Body Mass Index
CpG Islands
DNA Methylation
Inheritance Patterns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mexican Americans

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Identifiers

PMID: 24058506
DOI: 10.1371/journal.pone.0073950
PMCID: PMC3772804

Genes

ARHGAP9
CASP6
FRZB
FZD9
HOXA5
JAK3
MEST
MYOD1
NPY
PEG3
SMARCB1

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