Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction

Abstract excerpt

Aging is characterized by numerous molecular changes, such as accumulation of molecular damage and altered gene expression, many of which are linked to DNA methylation. Here, we characterize the blood DNA methylome across 16 age groups of mice and report numerous global, region- and site-specific features, as well as the associated dynamics of methylation changes. Transition of the methylome throughout lifespan...

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