Article
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
Nature genetics - 1 Jan 2022
Hawe Johann S, Wilson Rory, Schmid Katharina T, Zhou Li, Lakshmanan Lakshmi Narayanan, Lehne Benjamin C, Kühnel Brigitte, Scott William R, Wielscher Matthias, Yew Yik Weng, Baumbach Clemens, Lee Dominic P, Marouli Eirini, Bernard Manon, Pfeiffer Liliane, Matías-García Pamela R, Autio Matias I, Bourgeois Stephane, Herder Christian, Karhunen Ville, Meitinger Thomas, Prokisch Holger, Rathmann Wolfgang, Roden Michael, Sebert Sylvain, Shin Jean, Strauch Konstantin, Zhang Weihua, Tan Wilson L W, Hauck Stefanie M, Merl-Pham Juliane, Grallert Harald, Barbosa Eudes G V, Illig Thomas, Peters Annette, Paus Tomas, Pausova Zdenka, Deloukas Panos, Foo Roger S Y, Jarvelin Marjo-Riitta, Kooner Jaspal S, Loh Marie, Heinig Matthias, Gieger Christian, Waldenberger Melanie, Chambers John C
Abstract excerpt
We determined the relationships between DNA sequence variation and DNA methylation using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 SNP-CpG associations (methylation quantitative trait loci (meQTL), P < 10-14), including 467,915 meQTL that operate in trans. The meQTL are enriched for functionally relevant characteristics, including shared chromatin state, High-throuhgput...
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