Article
Genetic Loci and Metabolic States Associated With Murine Epigenetic Aging
2021-06-24
Abstract excerpt
Changes in DNA methylation (DNAm) are linked to aging. Here, we profile highly conserved CpGs in 339 predominantly female mice belonging to the BXD family for which we have deep longevity and genomic data. We use a ‘pan-mammalian’ microarray that provides a common platform for assaying the methylome across mammalian clades. We computed epigenetic clocks and tested associations with DNAm entropy, diet, weight, meta...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- d8344111-048a-5a4c-b933-11bd1abcefc5
- DOI
- 10.1101/2021.06.23.449634