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Article

Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci.

American journal of human genetics - 1 Jun 2017

Hannon Eilis, Weedon Mike, Bray Nicholas, O'Donovan Michael, Mill Jonathan

Abstract excerpt

Most genetic variants identified in genome-wide association studies (GWASs) of complex traits are thought to act by affecting gene regulation rather than directly altering the protein product. As a consequence, the actual genes involved in disease are not necessarily the most proximal to the associated variants. By integrating data from GWAS analyses with those from genetic studies of regulatory variation, it is...

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Identifiers

PMID: 28528868
DOI: 10.1016/j.ajhg.2017.04.013
PMCID: PMC5473725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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