Article

Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease

2022-04-16

Abstract excerpt

DNA methylation commonly occurs at cytosine-phosphate-guanine sites (CpGs) that can serve as biomarkers for many diseases. We analyzed whole genome sequencing data to identify DNA methylation quantitative trait loci (mQTLs) in 4,126 Framingham Heart Study participants. Our mQTL mapping identified 94,362,817 cis -mQTLvariant-CpG pairs (for 210,156 unique autosomal CpGs) at P <1e-7 and 33,572,145 trans -mQTL variant...

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Literature Corpus work: 4a2b477c-781f-5dc3-b10f-9faee5f62ee5
DOI: 10.1101/2022.04.13.22273848

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