Article

Characterizing concentration-dependent neural dynamics of 4-aminopyridine-induced epileptiform activity

2018-01-24

Abstract excerpt

Epilepsy remains one of the most common neurological disorders. In patients, it is characterized by unprovoked, spontaneous, and recurring seizures or ictal events. Typically, inter-ictal events or large bouts of population level activity can be measured between seizures and are generally asymptomatic. Decades of research has focused on understanding the mechanisms leading to the development of seizure-like activi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 79f8c6d5-0de1-5c7b-b1c1-298838ad4904
DOI: 10.1101/252726

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterizing concentration-dependent neural dynamics of 4-aminopyridine-induced epileptiform activityDOI 10.1101/252726Read

Pathophysiology of epilepsy.Semantic proximity Read

Excess interictal activity marks seizure prone cortical areas and mice in a genetic epilepsy modelSemantic proximity Read

Scn2a sodium channel mutation results in hyperexcitability in the hippocampus in vitro.Semantic proximity Read

DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue.Semantic proximity Read

Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic miceSemantic proximity Read

NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus.Semantic proximity Read

High-frequency oscillations arise through distinct mechanisms in models of α- synucleinopathy and channelopathy-induced epilepsySemantic proximity Read

Conditional Upregulation of KCC2 selectively enhances neuronal inhibition during seizuresSemantic proximity Read

Post-ictal generalized EEG suppression and seizure-induced mortality are reduced by enhancing dorsal raphe serotonergic neurotransmissionSemantic proximity Read

P2X7 receptor antagonism suppresses epileptiform-like activity in an inflammation-primed human iPSC-derived neuron model of drug-resistant epilepsySemantic proximity Read

Altered GluN2A levels reduce the emergence of seizure-like events in a rat model of <i>GRIN2A</i> haploinsufficiencySemantic proximity Read

A hyperthermic seizure unleashes a surge of spreading depolarizations in <i>Scn1a</i> deficient miceSemantic proximity Read