Article

A hyperthermic seizure unleashes a surge of spreading depolarizations in <i>Scn1a</i> deficient mice

2022-10-11

Abstract excerpt

Spreading depolarization (SD) is a massive wave of cellular depolarization that slowly migrates across the brain gray matter. Cortical SD is frequently generated following brain injury, while less is understood about its potential contribution to genetic disorders of hyperexcitability, such as SCN1A deficient epilepsy in which febrile seizure often contributes to disease initiation. Here we report that spontaneou...

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Literature Corpus work: 32dd6ded-5c20-5fd6-bd3f-1528d89c5892
DOI: 10.1101/2022.10.10.511466

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