Article

Excess interictal activity marks seizure prone cortical areas and mice in a genetic epilepsy model

2021-12-24

Abstract excerpt

Genetic epilepsies are often caused by variants in widely expressed genes, potentially impacting numerous brain regions and functions. For instance, gain-of-function (GOF) variants in the widely expressed Na + -activated K + channel gene KCNT1 alter basic neurophysiological and synaptic properties of cortical neurons, leading to developmental epileptic encephalopathy. Yet, aside from causing seizures, little is...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0252a0f-088f-5983-b0a7-14e655f760cb
DOI: 10.1101/2021.12.23.473545

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Excess interictal activity marks seizure prone cortical areas and mice in a genetic epilepsy modelDOI 10.1101/2021.12.23.473545Read

Novel Gain of Function Mouse Model of KCNT1-Related EpilepsySemantic proximity Read

The paradoxical effects of K <sup>+</sup> channel gain-of-function are mediated by GABAergic neuron hypoexcitability and hyperconnectivitySemantic proximity Read

Preictal dysfunctions of inhibitory interneurons paradoxically lead to their rebound hyperactivity and to Low-Voltage-Fast onset seizures in Dravet syndromeSemantic proximity Read

Impaired excitability of fast-spiking neurons in a novel mouse model of <i>KCNC1</i> epileptic encephalopathySemantic proximity Read

A hyperthermic seizure unleashes a surge of spreading depolarizations in <i>Scn1a</i> deficient miceSemantic proximity Read

EGR3 Deletion Rescues Developmental and Epileptic Encephalopathy in <i>Kcna1</i> -null MiceSemantic proximity Read

Altered GluN2A levels reduce the emergence of seizure-like events in a rat model of <i>GRIN2A</i> haploinsufficiencySemantic proximity Read

Kcnq2/Kv7.2 controls the threshold and bihemispheric symmetry of cortical spreading depolarizationSemantic proximity Read

Cortical hyperexcitability and epileptogenesis: Understanding the mechanisms of epilepsy - part 2.Semantic proximity Read

Early EEG and behavioral alterations in Dravet miceSemantic proximity Read

Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels.Semantic proximity Read

Aberrant Local Synchrony in Distinct Mouse Models of Epileptic EncephalopathySemantic proximity Read