Article

P2X7 receptor antagonism suppresses epileptiform-like activity in an inflammation-primed human iPSC-derived neuron model of drug-resistant epilepsy

2024-09-01

Abstract excerpt

<h4>Background: </h4> and Purpose Neuroinflammation is increasingly recognized to contribute to drug-resistant epilepsy. Activation of the ATP-gated P2X7 receptor (P2X7R) has emerged as an important upstream mechanism and increased P2X7R expression is present in the seizure focus in rodent models and patients. Pharmacologic antagonism of the P2X7R can attenuate seizures in rodents but this has not been explored in...

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Literature Corpus work: 99d7556f-fe2d-54ba-b97c-4afcfa5d9ed3
DOI: 10.22541/au.172516541.12231170/v1

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