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Article

DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue.

Gene therapy - 1 Oct 2016

Avaliani N, Andersson M, Runegaard A H, Woldbye D, Kokaia M

Abstract excerpt

Epilepsy is a neurological disorder with a prevalence of ≈1% of general population. Available antiepileptic drugs (AEDs) have multiple side effects and are ineffective in 30% of patients. Therefore, development of effective treatment strategies is highly needed, requiring drug-screening models that are relevant and reliable. We investigated novel chemogenetic approach, using DREADDs (designer receptors...

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Source

Identifiers

PMID: 27416078
DOI: 10.1038/gt.2016.56

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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