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Article

New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome

24 Feb 2020

Abstract excerpt

Abstract Objective To pinpoint the earliest cellular defects underlying seizure onset (epileptogenic period) during perinatal brain development in a new zebrafish model of Dravet syndrome (DS) and to investigate potential disease‐modifying activity of the 5HT 2 receptor agonist fenfluramine. Methods We used CRISPR/Cas9 mutagenesis to introduce a missense mutation, designed to perturb ion transport function in all...

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PMID: 32096222
DOI: 10.1111/epi.16456

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