Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early rescue of interneuron disease trajectory in developmental epilepsies.

Current opinion in neurobiology - 1 Feb 2016

Siehr Meagan S, Noebels Jeffrey L

Abstract excerpt

The discovery of over 150 monogenic epilepsies and advances in early genetic diagnoses have launched a search for molecular strategies and developmental timetables to reverse or even prevent the course of these debilitating brain disorders. Orthologous rodent models of key disease genes are providing important examples of the range of targets, and serve as valuable test systems for perinatal therapeutic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Disease Progression
Share to Epilepsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Hormones

Share to Interneurons

Share to Neurogenesis

Share to Neurotransmitter Agents

Source

Open in PubMed Open full text

Identifiers

PMID: 26517286
DOI: 10.1016/j.conb.2015.10.007
PMCID: PMC4738159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early rescue of interneuron disease trajectory in developmental epilepsies.PMID 26517286Read ↗

Axonopathy and altered synaptic development in early hippocampal epileptogenesis of Dravet syndromeSemantic proximity Read ↗

Interneuronopathies and their role in early life epilepsies and neurodevelopmental disordersSemantic proximity Read ↗

Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum.Semantic proximity Read ↗

Molecular diversity and lineage commitment of human interneuron progenitorsSemantic proximity Read ↗

IGF-1 IMPACTS NEOCORTICAL INTERNEURON CONNECTIVITY IN EPILEPTIC SPASM GENERATION AND RESOLUTIONSemantic proximity Read ↗

Animal models for neuropsychiatric disorders: prospects for circuit intervention.Semantic proximity Read ↗

Identifying developing interneurons as a potential target for multiple genetic autism risk factors in human and rodent forebrainSemantic proximity Read ↗

Dysregulation of Neuropilin-2 Expression in Inhibitory Neurons Impairs Hippocampal Circuit Development Leading to Autism-Epilepsy PhenotypeSemantic proximity Read ↗

Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet SyndromeSemantic proximity Read ↗

Genetic basis of sleep phenotypes and rare neurodevelopmental syndromes reveal shared molecular pathways.Semantic proximity Read ↗

The biology of epilepsy genes.Semantic proximity Read ↗

Dysregulation of Neuropilin-2 Expression in Inhibitory Neurons Impairs Hippocampal Circuit Development and Enhances Risk for Autism-Related Behaviors and SeizuresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.