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Article

Proteomic signature of the Dravet syndrome in the genetic Scn1a-A1783V mouse model

16 Jun 2021

Abstract excerpt

BACKGROUND: Dravet syndrome is a rare, severe pediatric epileptic encephalopathy associated with intellectual and motor disabilities. Proteomic profiling in a mouse model of Dravet syndrome can provide information about the molecular consequences of the genetic deficiency and about pathophysiological mechanisms developing during the disease course. METHODS: A knock-in mouse model of Dravet syndrome with Scn1a...

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PMID: 34144125
DOI: 10.1016/j.nbd.2021.105423

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