Article
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.
Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009
Sandoz Guillaume, Douguet Dominique, Chatelain Franck, Lazdunski Michel, Lesage Florian
Abstract excerpt
Mechanosensitive K(+) channels TREK1 and TREK2 form a subclass of two P-domain K(+) channels. They are potently activated by polyunsaturated fatty acids and are involved in neuroprotection, anesthesia, and pain perception. Here, we show that acidification of the extracellular medium strongly inhibits TREK1 with an apparent pK near to 7.4 corresponding to the physiological pH. The all-or-none effect of pH...
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