Article
H(+)-gated cation channels.
Annals of the New York Academy of Sciences - 30 Apr 1999
Waldmann R, Champigny G, Lingueglia E, De Weille J R, Heurteaux C, Lazdunski M
Abstract excerpt
H(+)-gated cation channels are members of a new family of ionic channels, which includes the epithelial Na+ channel and the FMRFamide-activated Na+ channel. ASIC, the first member of the H(+)-gated Na+ channel subfamily, is expressed in brain and dorsal root ganglion cells (DRGs). It is activated by pHe variations below pH 7. The presence of this channel throughout the brain suggests that the H+ might play an...
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