Article

Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants

2024-06-20

Abstract excerpt

<title>Abstract</title> <p>Acid-sensing ion channels (ASICs) are trimeric proton-gated cation channels that play a role in neurotransmission and pain sensation. The snake venom-derived peptides, mambalgins, exhibit potent analgesic effects in rodents by inhibiting central ASIC1a and peripheral ASIC1b. Despite their distinct species- and subtype-dependent pharmacology, previous structure-function studies have focu...

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Literature Corpus work: 15fb4d7b-c763-53a5-80a8-85b1124ecfca
DOI: 10.21203/rs.3.rs-4539352/v1

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