Article

CpG island turnover events predict evolutionary changes in enhancer activity

2023-05-09

Abstract excerpt

Genetic changes that modify the function of transcriptional enhancers have been linked to the evolution of biological diversity across species. Multiple studies have focused on the role of nucleotide substitutions, transposition, and insertions and deletions in altering enhancer function. Here we show that turnover of CpG islands (CGIs), which contribute to enhancer activation, is broadly associated with changes i...

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Literature Corpus work: 79ddb817-6bd8-568a-8e4c-a5139af329bf
DOI: 10.1101/2023.05.09.540063

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