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Article

Enhancer reprogramming in mammalian genomes.

BMC bioinformatics - 10 Sept 2018

Flores Mario A, Ovcharenko Ivan

Abstract excerpt

BACKGROUND: Transcription factor binding site (TFBS) loss, gain, and reshuffling within the sequence of a regulatory element could alter the function of that regulatory element. Some of the changes will be detrimental to the fitness of the species and will result in gradual removal from a population, while other changes would be either beneficial or just a part of genetic drift and end up being fixed in a...

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Identifiers

PMID: 30200877
DOI: 10.1186/s12859-018-2343-7
PMCID: PMC6131754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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