Article

Emergence of new enhancers at late DNA replicating regions

2022-12-23

Abstract excerpt

Enhancers are fast-evolving genomic sequences that control spatiotemporal gene expression patterns. By examining enhancer turnover across mammalian species and in multiple tissue types, we uncovered a relationship between the emergence of novel enhancers and genome organization as a function of germline DNA replication time. While enhancers are most abundant in euchromatic regions, new enhancers emerged almost twi...

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Literature Corpus work: a1a53c2f-b3fe-50fc-a8fc-b5421041e9d8
DOI: 10.1101/2022.12.22.521323

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