Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emergence of enhancers at late DNA replicating regions.

Nature communications - 24 Apr 2024

Cornejo-Páramo Paola, Petrova Veronika, Zhang Xuan, Young Robert S, Wong Emily S

Abstract excerpt

Enhancers are fast-evolving genomic sequences that control spatiotemporal gene expression patterns. By examining enhancer turnover across mammalian species and in multiple tissue types, we uncover a relationship between the emergence of enhancers and genome organization as a function of germline DNA replication time. While enhancers are most abundant in euchromatic regions, enhancers emerge almost twice as often...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Replication
Share to DNA Transposable Elements
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Gene Expression Regulation

Share to Genome

Share to Organ Specificity

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 38658544
DOI: 10.1038/s41467-024-47391-5
PMCID: PMC11043393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emergence of enhancers at late DNA replicating regions.PMID 38658544Read ↗

Emergence of new enhancers at late DNA replicating regionsSemantic proximity Read ↗

Modeling the Evolutionary Architectures of Transcribed Human Enhancer Sequences Reveals Distinct Origins, Functions, and Associations with Human Trait Variation.Semantic proximity Read ↗

Modeling the evolutionary architectures of human enhancer sequences reveals distinct origins, functions, and associations with human-trait variationSemantic proximity Read ↗

Enhancer reprogramming in mammalian genomes.Semantic proximity Read ↗

CpG island turnover events predict evolutionary changes in enhancer activitySemantic proximity Read ↗

Evolution of transposable element-derived enhancer activitySemantic proximity Read ↗

Transposable elements generate regulatory novelty in a tissue-specific fashionSemantic proximity Read ↗

Functional characterization of enhancer evolution in the primate lineage.Semantic proximity Read ↗

EnhancerTracker: Comparing cell-type-specific enhancer activity of DNA sequence triplets via an ensemble of deep convolutional neural networksSemantic proximity Read ↗

Function and constraint in enhancers with multiple evolutionary originsSemantic proximity Read ↗

Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammalsSemantic proximity Read ↗

Deep learning reveals evolutionary conservation and divergence of sequence properties underlying gene regulatory enhancers across mammalsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.