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Article

The contribution of evolutionarily volatile promoters to molecular phenotypes and human trait variation.

Genome biology - 4 Apr 2022

Young Robert S, Talmane Lana, Marion de Procé Sophie, Taylor Martin S

Abstract excerpt

BACKGROUND: Promoters are sites of transcription initiation that harbour a high concentration of phenotype-associated genetic variation. The evolutionary gain and loss of promoters between species (collectively, termed turnover) is pervasive across mammalian genomes and may play a prominent role in driving human phenotypic diversity. RESULTS: We classified human promoters by their evolutionary history during the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35379293
DOI: 10.1186/s13059-022-02634-w
PMCID: PMC8978360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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