Article

Functional Molecular Switches of Mammalian G Protein-Coupled Bitter-Taste Receptors

2020-10-23

Abstract excerpt

Bitter taste receptors (TAS2Rs) are a poorly understood subgroup of G protein-coupled receptors (GPCRs). The experimental structure of these receptors has yet to be determined, and key-residues controlling their function remain mostly unknown. We designed an integrative approach to improve comparative modeling of TAS2Rs. Using current knowledge on class A GPCRs and existing experimental data in the literature as c...

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Literature Corpus work: 799354d3-c445-5ba9-8c92-679228ccb848
DOI: 10.1101/2020.10.23.348706

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