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Article

Functional molecular switches of mammalian G protein-coupled bitter-taste receptors.

Cellular and molecular life sciences : CMLS - 1 Dec 2021

Topin Jérémie, Bouysset Cédric, Pacalon Jody, Kim Yiseul, Rhyu Mee-Ra, Fiorucci Sébastien, Golebiowski Jérôme

Abstract excerpt

Bitter taste receptors (TAS2Rs) are a poorly understood subgroup of G protein-coupled receptors (GPCRs). The experimental structure of these receptors has yet to be determined, and key-residues controlling their function remain mostly unknown. We designed an integrative approach to improve comparative modeling of TAS2Rs. Using current knowledge on class A GPCRs and existing experimental data in the literature as...

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Identifiers

PMID: 34687318
DOI: 10.1007/s00018-021-03968-7
PMCID: PMC11073308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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