Article
Functional molecular switches of mammalian G protein-coupled bitter-taste receptors.
Cellular and molecular life sciences : CMLS - 1 Dec 2021
Topin Jérémie, Bouysset Cédric, Pacalon Jody, Kim Yiseul, Rhyu Mee-Ra, Fiorucci Sébastien, Golebiowski Jérôme
Abstract excerpt
Bitter taste receptors (TAS2Rs) are a poorly understood subgroup of G protein-coupled receptors (GPCRs). The experimental structure of these receptors has yet to be determined, and key-residues controlling their function remain mostly unknown. We designed an integrative approach to improve compar...
Topics
- Amino Acid Sequence
- Humans
- Mutagenesis, Site-Directed
- Mutation
- Protein Conformation
- Receptors, G-Protein-Coupled
- Taste
- Taste Receptors, Type 2