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Article

Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists.

Proceedings of the National Academy of Sciences of the United States of America - 7 Mar 2017

Kim Soo-Kyung, Chen Yalu, Abrol Ravinder, Goddard William A, Guthrie Brian

Abstract excerpt

The sweet taste in humans is mediated by the TAS1R2/TAS1R3 G protein-coupled receptor (GPCR), which belongs to the class C family that also includes the metabotropic glutamate and γ-aminobutyric acid receptors. We report here the predicted 3D structure of the full-length TAS1R2/TAS1R3 heterodimer, including the Venus Flytrap Domains (VFDs) [in the closed-open (co) active conformation], the cysteine-rich domains...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28228527
DOI: 10.1073/pnas.1700001114
PMCID: PMC5347580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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