Article
Chemosensory bitter taste receptors (T2Rs) are activated by multiple antibiotics.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2019
Jaggupilli Appalaraju, Singh Nisha, De Jesus Vivianne Cruz, Gounni Mohamed Soussi, Dhanaraj Premnath, Chelikani Prashen
Abstract excerpt
Many medications including antibiotics taste bitter. The potency of these antibiotics on the 25 bitter taste receptors (T2Rs) in humans remains poorly understood. Here we characterize by sensory and structure-function analyses how antibiotics frequently used to treat airway infections in cystic fibrosis activate multiple human T2Rs. The potency of the broad-spectrum antibiotics, tobramycin, levofloxacin, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.