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Article

Bitter Chinese Herbal Medicine Exerts Pharmacological Effects via TAS2Rs: A Systematic Review from Natural Ligands to Therapeutic Potential.

International journal of molecular sciences - 27 Mar 2026

Li Lian, Dong Ruitong, Feng Shibu, Huang Yan, Li Xin, Que Hanyun, Li Huan, Wang Peng, Fey Leu-Kim, Zhang Yi, Cong Zhaotong, Zhang Sanyin

Abstract excerpt

Bitter compounds may function not only as taste substances but also as important active constituents mediating therapeutic effects. Their recognition is primarily mediated by bitter taste receptors (TAS2Rs), which exert pharmacological effects, such as regulating glucose metabolism, anti-inflammatory properties, and immune modulation, aligning closely with the therapeutic effects of bitter Chinese herbal medicine...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41977260
DOI: 10.3390/ijms27073073
PMCID: PMC13073723

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