Article

A CRISPR activation screen identifies FBXO22 as an E3 ligase supporting targeted protein degradation

2023-09-16

Abstract excerpt

Targeted protein degradation (TPD) represents a potent chemical biology paradigm that leverages the cellular degradation machinery to pharmacologically eliminate specific proteins of interest. Although multiple E3 ligases have been discovered to facilitate TPD, there exists a compelling requirement to diversify the pool of E3 ligases available for such applications. This expansion will broaden the scope of potenti...

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Identifiers and source

Literature Corpus work: 8fd92278-e46a-56cf-92ea-1886eebfa595
DOI: 10.1101/2023.09.15.557708

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