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NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablation

2020-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Heterologously-expressed bacterial nitroreductase (NTR) enzymes sensitize eukaryotic cells to prodrugs such as metronidazole (MTZ), enabling selective cell ablation paradigms that have expanded studies of cell function and regeneration in vertebrate systems. However, first-generation NTRs require confoundingly toxic prodrug treatments (e.g. 10 mM MTZ) and some cell types have proven resistant. W...

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Identifiers and source

Literature Corpus work
0bdd88f5-2787-502c-ad80-5018064b297a
DOI
10.1101/2020.05.22.111427
Open publication

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NTR 2.0: a rationally-engineered prodrug converting enzyme with substantially enhanced efficacy for targeted cell ablationDOI 10.1101/2020.05.22.111427
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