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Article

The NTR/Prodrug Revolution: Tools for Controlling Cell Loss and Regeneration

2026-03-02

Abstract excerpt

Here, we review the history, advancements, and broad utility of the NTR/prodrug system, and suggest future strategies for developing versatile ablation models. As a chemogenetic tool, the nitroreductase (NTR)/prodrug system enables precise spatiotemporal control over cell ablation. The technology leverages bacterial nitroreductase enzymes (e.g., nfsB) to convert inert prodrugs into cytotoxic agents, thereby allowi...

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Literature Corpus work
3b3c4ba9-5f4a-5694-a633-cd004be63a34
DOI
10.20944/preprints202602.2055.v1
Open publication

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The NTR/Prodrug Revolution: Tools for Controlling Cell Loss and RegenerationDOI 10.20944/preprints202602.2055.v1
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