Article

Chemical and genetic screens identify new regulators of tetracycline-inducible gene expression system in mammalian cells

2022-03-16

Abstract excerpt

<h4>ABSTRACT</h4> The tetracycline repressor (tetR)-regulated system is a widely used tool to specifically control gene expression in mammalian cells. Based on this system, we generated a human osteosarcoma cell line which allows for inducible expression of an EGFP-fusion of the TAR DNA-binding protein 43 (TDP-43), which has been linked to neurodegenerative diseases. Consistent with previous findings, TDP-43 over...

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Literature Corpus work: 6d20434e-c90a-55f3-808d-7070f3cf3e0c
DOI: 10.1101/2022.03.16.484587

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