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Maternal immune activation: Implications for neuropsychiatric disorders

18 Aug 2016

Abstract excerpt

Epidemiological evidence implicates maternal infection as a risk factor for autism spectrum disorder and schizophrenia. Animal models corroborate this link and demonstrate that maternal immune activation (MIA) alone is sufficient to impart lifelong neuropathology and altered behaviors in offspring. This Review describes common principles revealed by these models, highlighting recent findings that strengthen their...

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PMID: 27540164
DOI: 10.1126/science.aag3194

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