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Article

Maternal immune activation with high molecular weight poly (I:C) induces selective depressive-like phenotype in adult offspring.

Translational psychiatry - 3 Mar 2026

Santoni Michele, Mastio Andrea, Concas Luca, Mostallino Rafaela, Herres Anna, Sagheddu Claudia, Castelli M Paola, Frau Roberto, Muntoni Anna Lisa, Pistis Marco

Abstract excerpt

Maternal immune activation (MIA) during pregnancy may increase the risk for neurodevelopmental disorders such as schizophrenia and autism in offspring. Preclinical and human evidence support a potential role for MIA in the development of depressive symptoms in offspring. Among animal models of MIA, prenatal treatment with the synthetic viral mimetic polyinosinic-polycytidylic acid [poly (I:C)] is well established...

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Behavior, Animal
Cytokines
Depression
Disease Models, Animal
Poly I-C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prenatal Exposure Delayed Effects

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Open in PubMed Open full text

Identifiers

PMID: 41775700
DOI: 10.1038/s41398-026-03926-6
PMCID: PMC12982799

Genes

MIA
FST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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